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Miklós M, Cseri K, Laczkó L, Kardos G, Fraune S,Tökölyi J (2023) Environmental bacteria increase population growth of Hydra at low temperature. Front. Microbiol.  https://doi.org/10.3389/fmicb.2023.1294771

Domin H, Zimmermann J, Taubenheim J, Fuentes Reyes G, Saueressig L, Prasse D, Höppner M, Schmitz RA, Hentschel U, Kaleta C, Fraune S (2023) Sequential host-bacteria and bacteria-bacteria interactions determine the microbiome establishment of Nematostella vectensis. Microbiomehttps://doi.org/10.1186/s40168-023-01701-z

Baldassarre L, Reitzel A, Fraune S, (2023) Genotype-environment interactions determine microbiota plasticity in the sea anemone Nematostella vectensis. PLoS Biol. 21(1): e3001726. https://doi.org/10.1371/journal.pbio.3001726



Schmittmann L, Rahn T, Busch K, Fraune S, Pita L, Hentschel U. (2022) Sponge-symbiont stability in spite of antibiotic-induced microbiome disturbance. Environ. Microbiol. 24: 6392-6410, https://doi.org/10.1111/1462-2920.16249

Puntin G., Sweet M, Fraune F, Medina M., Weiss V, Ziegler M (2022) Harnessing the power of model organisms to unravel coral holobiont complexity. Microbiol. Mol. Biol. Reviews, 21;86(4):e0005322, https://doi.org/10.1128/mmbr.00053-22

Baldassarre L, Ying H, Franzenburg S, Reitzel A, Fraune S (2022) Microbiota mediated plasticity promotes thermal adaptation in the sea anemone Nematostella vectensisNat. Commun. 13(1):3804, https://doi.org/10.1038/s41467-022-31350-z

Bathia J, Schröder K, Fraune S, Lachnit T, Rosenstiel P, Bosch TCG (2022) Symbiotic algae of Hydra viridissima play a key role in maintaining homeostatic bacterial colonization. Front. Microbiol. 13:869666, https://doi.org/10.3389/fmicb.2022.869666

Taubenheim T, Miklós M, Tökölyi J, Fraune S (2022) Population differences and host species drive microbiome diversity in Hydra, Front Microbiol, https://doi.org/10.3389/fmicb.2022.799333

Ying H, Hayward DC, Klimovich A, Bosch TCG, Baldassarre L, Neeman T, Forêt S, Huttley G, Reitzel AM, Fraune S, Ball EE, Miller DJ (2022) The role of DNA methylation in genome defence in Cnidaria and other invertebrates, Mol Biol Evol 39(2):msac018,  https://doi.org/10.1093/molbev/msac018


Baldassarre L*, Levy S*, Bar-Shalom R, Steindler L, Lotan T, Fraune S (2021) Contribution of maternal and paternal transmission to bacterial colonization in Nematostella vectensis, Front. Microbiol., doi: 10.3389/fmicb.2021.726795

Taubenheim J, Kortmann C, Fraune S (2021) Function and evolution of nuclear receptors in environmental-dependent postembryonic development, Front Cell Dev Biol. 9:653792, doi: 10.3389/fcell.2021.653792.



Taubenheim J, Willoweit-Ohl D, Knop M, Franzenburg S, He J., Bosch TCG, Fraune S (2020) Bacteria-and temperature-regulated peptides modulate beta-catenin signaling in Hydra, Proc Natl Acad Sci USA, DOI: 10.1073/pnas.2010945117

Minten-Lange T, Fraune S (2020) Hydra and Curvibacter: An intimate crosstalk at the epithelial interface, in Cellular Dialogues in the Holobiont, 79-89, 2020. Doi: 10.1201/9780429277375-6

Johnke J, Fraune S, Bosch TCG, Hentschel U, Schulenburg H (2020) Bdellovibrio and like organisms are predictors of microbiome diversity in distinct host groups. Microbial Ecol. 1–6 doi: 10.1101/627455



Cooke I; Oliver M; Casey W; Consortium Australian Acad Sci Bod et al. (2019) Molecular techniques and their limitations shape our view of the holobiont, Zoology 137 doi: 10.1016/j.zool.2019.125695 125695

Rausch P, Rühlemann M et al., (2019) Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms. Microbiome.14;7(1):133, doi: 10.1186/s40168-019-0743-1.

Lange J, Fraune S, Bosch TCG, Lachnit T. The neglected part of the microbiome: Prophage TJ1 regulates the bacterial community of the metaorganism Hydra, bioRxiv, doi: https://doi.org/10.1101/607325

Mortzfeld BM*, Taubenheim J*, Klimovich AV, Fraune S, Bosch TCG (2019) Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways. Nature Comm., 10 (1), 3257, doi: 10.1038/s41467-019-11136-6

Sieber M, Pita L, Weiland-Braeuer N, Dirksen P, Wang J, Mortzfeld B, Franzenburg S, Schmitz RA, Baines JF, Fraune S, Hentschel U, Schulenburg H, Bosch TCG, Traulsen A (2019) Neutrality in the metaorganism. PLoS Biol. 17 (6), e3000298. doi: https://doi.org/10.1101/367243.

Jaspers C, Fraune S, Consortium of Australian Academy of Science Boden Research Conference Participants, Arnold AE, Miller DJ, Bosch TCG, Voolstra CR (2019) Resolving structure and function of metaorganisms through a holistic framework combining reductionist and integrative approaches. Zoology, DOI: 10.1016/j.zool.2019.02.007


Hamada M, Schröder K, Bathia J, Kürn U, Fraune S, Khalturina M, Khalturin K, Shinzato C, Satoh N, Bosch TCG (2018); Metabolic co-dependence drives the evolutionarily ancient Hydra-Chlorella symbiosis. eLife 7.e35122. doi: 10.7554/eLife.35122

Domin H, Zurita-Gutiérrez YH, Scotti M, Buttlar J, Hentschel Humeida U, Fraune S (2018). Predicted bacterial interactions affect in vivo microbial colonization dynamics in Nematostella. Front Microbiol., 9, 728, https://doi.org/10.3389/fmicb.2018.00728

Mortzfeld BM, Taubenheim J, Fraune S, Klimovich AV, Bosch TCG (2018). Stem cell transcription factor FoxO controls microbiome resilience in Hydra. Front Microbiol., 9, 629, https://doi: 10.3389/fmicb.2018.00629

Wein T, Dagan T, Fraune S, Bosch TCG, Reusch TB, Hülter NF Priority rules in microbiota colonization dynamics (2018). Front Microbiol., 9 https://doi:10.3389/fmicb.2018.00443

Bang C, Dagan T, Deines P, Dubilier N, Duschl WJ, Fraune S, Hentschel U, Hirt H, Hülter N, Lachnit T, Picazo D, Pita L, Pogoreutz C, Radecker N, Saad MM, Schmitz RA, Schulenburg H, Voolstra CR, Weiland-Brauer N, Ziegler M, Bosch TCG (2018). Metaorganisms in extreme environments: do microbes play a role in organismal adaptation? Zoology, 15, 2018. https://doi.org/10.1016/j.zool.2018.02.004


Li XY, Lachnit T, Fraune S, Bosch TCG,Traulsen A, Sieber M (2017) Temperate phages as self-replicating weapons in bacterial competition. J. R. Soc. Interface, 14(137), doi: 10.1098/rsif.2017.0563

Pietschke C, Treitz C, Forêt S, Schultze A, Künzel S, Tholey A, Bosch TCG, Fraune S (2017) Host modification of a bacterial quorum sensing signal induces a phenotypic switch in bacterial symbionts. Proc Natl Acad Sci USA, 114(40):E8488-E8497

Augustin R, Schröder K, Murillo Rincón AP, Fraune S, Anton-Erxleben F, Herbst E-M, Wittlieb J, Schwentner M, Grötzinger J, Wassenaar TM, Bosch TCG (2017) A secreted antibacterial neuropeptide shapes the microbiome in Hydra. Nature Comm., 8(1):69


Pita L, Fraune S, Hentschel U (2016) Emerging sponge models of animal-microbe symbioses, Frontiers in Microbiology 7, 2102. doi: 10.3389/fmicb.2016.02102

Fraune S, Forét S, Reitzel AM (2016) Using Nematostella vectensis to study the interactions between genome, epigenome, and bacteria in a changing environment, Frontiers in Marine Science 3, 148, doi: 10.3389/fmars.2016.00148


Mortzfeld BM, Urbanski S, Reitzel AM, Künzel S,Technau U, Fraune S (2015) Response of bacterial colonization in Nematostella vectensis to development, environment and biogeography, Environ. Microbiol. doi: 10.1111/1462-2920.12926

Li XY, Pietschke C, Fraune S, Altrock PM, Bosch TCG, Traulsen A (2015) Which games are growing bacterial populations playing? Interface, DOI: 10.1098/rsif.2015.0121

Fraune S, Franzenburg S, Schröder S, Augustin R, Anton-Erxleben F, Bosch TCG. (2015) Bacteria-bacteria interactions within the microbiota of the ancestral metazoan Hydra contribute to fungal resistance ISME J. 9:1543-56


Grasis J, Lachnit T, Anton-Erxleben F, Lim YM, Schmieder R, Fraune S et al. (2014) Species-Specific Viromes in the Ancestral Holobiont Hydra. PLoS ONE, 9(10):e109952.

Bosch TCG, Adamska M, Augustin R, Domazet-Loso T, Foret S, Fraune S, et al. (2014) How do environmental factors influence life cycles and development? An experimental framework for early-diverging metazoans. Bioessays. 2014 Sep 10. doi: 10.1002/bies.201400065.


Franzenburg S, Walter J, Künzel S, Wang J, Baines JF, Bosch TCG, Fraune S. (2013) Distinct antimicrobial peptide expression determines host species-specific bacterial associations. Proc Natl Acad Sci USA, 110(39):E3730-8

Franzenburg S, Fraune S, Altrock PM, Künzel S, Baines JF, Traulsen A, Bosch TCG (2013) Bacterial colonization of Hydra hatchlings follows a robust temporal pattern. ISME J. 7(4):781-90, Featured in F1000


Franzenburg S, Fraune S, Künzel S, Baines JF, Domazet-Lošo T, Bosch TCG1 (2012) MyD88 deficient Hydra reveal an ancient function of TLR-signaling in sensing bacterial colonizers. Proc. Natl. Acad. Sci. USA 109 (47):19374-9, Featured in F1000

Fraune J, Alsheimer M, Volff JN, Busch K, Fraune S, Bosch TCG, Benavente R (2012) Hydra meiosis reveals unexpected conservation of structural synaptonemal complex proteins across metazoans. Proc. Natl. Acad. Sci. USA, 109:16588-16593

Augustin R, Fraune S, Franzenburg S, Bosch TCG (2012) Where simplicity meets complexity: hydra, a model for host-microbe interactions. Adv Exp Med Biol, 710:71-81


Fraune S, R Augustin, TCG Bosch (2011) Embryo protection in contemporary immunology: Why bacteria matter. Commun. Integr. Biol. (4):369-72


Fraune S , Augustin R, Anton-Erxleben F, Wittlieb J, Gelhaus C, Klimovich VB, Samoilovich MP, and Bosch TCG (2010) In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides Proc. Natl. Acad. Sci. USA, 107,18067-18072; Featured as “Research Highlights” in Nature Immunology (2010) 11, 1083

Fraune S and Bosch TCG (2010) Why bacteria matter in animal development and evolution. Bioessays 32 (7)

Chapman JA , Kirkness EF, Simakov O, ... Khalturin K, Hemmrich G, Franke A, Augustin R, Fraune S, ..Venter JC, Technau U, Hobmayer B, Bosch TCG, Holstein TW, Fujisawa T, Bode HR, David CN, Rokhsar DS, Steele RE (2010). The dynamic genome of Hydra. Nature, 464(7288):592-6

Augustin R, Fraune S, and Bosch TCG (2010) How Hydra senses and destroys microbes. Sem. Immunol., 22: 54–58.


Khalturin K, Hemmrich G, Fraune S and Bosch TCG (2009) More than just orphans: are taxonomically-restricted genes important in evolution? Trends Genet. 25: 404-413.

Fraune S, Abe Y, Bosch TCG (2009) Disturbing epithelial homeostasis in the metazoan Hydra leads to drastic changes in associated microbiota. Environ. Microbiol. 11: 2361-2369.

Jaenicke E, Fraune S, May S, Irmak P, Augustin R, Meesters C, Decker H, and Zimmer M (2009) Is activated hemocyanin instead of phenoloxidase involved in immune response in woodlice? Dev. Comp. Immunol. 33(10):1055-63.

Anton-Erxleben F, Thomas A, Wittlieb J, Fraune S, Bosch TCG (2009) Plasticity of epithelial cell shape in response to upstream signals: a whole-organism study using transgenic Hydra. Zoology 112: 185-94.

Bosch TCG, Augustin R, Anton-Erxleben F, Fraune S, Hemmrich G, et al (2009) Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence. Dev. Comp. Immunol. 33: 559-69.


Fraune S, Zimmer M (2008) Host-specificity of environmentally transmitted Mycoplasma-like isopod symbionts. Environ. Microbiol. 10: 2497-504.


Fraune S, Bosch TCG (2007) Long-term maintenance of species-specific bacterial microbiota in the basal metazoan Hydra. Proc. Natl. Acad.Sci. USA 104: 13146-51.